The Friday Seminar Series in Biology presents: “Lessons from four-legged patients: what mouse models can tell us about human genetic diseases,” presented by Mira Krendel, Ph.D. Dr. Mira Krendel is an associate professor for the Department of Cell and Developmental Biology at the State University of New York Upstate Medical University where she teaches and conducts biomedical research that focuses on the relationship between cytoskeletal proteins and diseases, using model organisms. Her research topic is of potential interest to any biologist, but especially to those with interests in the pre health professions.
Synopsis of presentation: Model organisms can be used to test whether the loss of function of a specific gene results in disease. Using a knockout mouse model, we discovered that the loss of a cytoskeletal protein, myosin 1e (Myo1e), leads to kidney disease in mice, which led us to predict that mutations in the MYO1E gene in humans may cause familial kidney disorders. As predicted, several families with mutations in MYO1E and associated kidney disease have been identified in clinical genetic studies. Myo1e is a component of cell-cell junctions between epithelial cells in the glomerulus, a portion of the nephron that plays a key role in selective filtration of proteins. Our studies using a variety of model systems, including transgenic mice, cultured kidney cells, and fission yeast show that mutations in the human MYO1E gene disrupt domains important for Myo1e functions in cells, leading to defects in protein filtration and subsequent kidney failure.
This seminar is hosted by the Biology Department and will take place 4 pm Friday April 3rd in Science I room 121.
About this seminar series: This series is offered weekly to provide our student community with opportunities to learn about scientific research and professions. Speakers may include our own department faculty or students, as well as biologists and other professionals from elsewhere. All are welcome.